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Your doctor can discuss with you how to manage side effects and whether youll need to stop taking Prolia due to side effects. Prolia also carries a warning about hypocalcemia, which is a low level of calcium in the blood. They may help you identify other possible causes or suggest ways to help manage hair loss. Theyre commonly used to treat osteoporosis. DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. To learn more about this, see the How is Prolia administered? section below. Although its rare, your doctor may give you the option to self-inject Prolia at home. * Sex and gender exist on spectrums. People administered concomitant immunosuppressant agents (such as prednisone or cyclosporine) or with impaired immune systems may be at an even higher risk. Pregnancy. eHealthMe is studying from 146,783 Calcium users for its effectiveness, alternative drugs and more. Its recommended that calcium and vitamin D supplements be taken If you have low calcium levels, you should not take Prolia. Throw away a prefilled syringe after one use, even if there is still medicine left inside. Every 6 months youll get another dose of Prolia. Prolia may be used off-label for RA, if you have a high risk for bone fractures. that's no different than scheduling a visit to the dentist twice a year. High cholesterol itself doesnt cause any symptoms. Your doctor can also help you decide if the benefits of Prolia treatment outweigh your risks of side effects. If you have low blood calcium, it may get worse during treatment. Also describe any vitamins, herbs, or supplements you use. Compared to other osteoporosis treatments, only Proliais1 shot every 6 months. Use effective birth control while using this medicine and for at least 5 months after your last dose. For a detailed breakdown of Prolia versus Xgeva, check out this article. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses. Research has shown people who take Prolia are at an increased risk of serious infections leading to hospitalizations, including endocarditis and serious infections of the skin, abdominal, urinary tract, and ear. Your doctor or another healthcare professional will inject Prolia under the skin in one of the following areas: Prolia doses are given as an injection by healthcare professionals once every 6 months. These side effects include: Your risk for these serious side effects may be higher if youre older and have certain dental procedures. While you are using Prolia, you should not receive Xgeva, another brand of denosumab. Heres a sample meal plan thats packed with nutritious foods just for. According to the American Dental Association, your risk of this problem may increase if you receive denosumab (the active drug in Prolia) for longer than 2 years. Prolia (denosumab) injection, for subcutaneous use. For information about the difference between sex and gender, see this article. Patients in the study may take other drugs besides Prolia and Calcium. It could harm the unborn baby or cause birth defects. (To learn more, see the Precautions for Prolia section below.). Learn more about the FRAX score and the treatment options for, Medical News Today has strict sourcing guidelines and draws only from peer-reviewed studies, academic research institutions, and medical journals and associations. (Vitamin D helps your body absorb calcium.) Learn more about the unique risk factors for osteoporosis in, Osteoporosis weakens bones, which leads to breaks in the hips, wrists, and spine. Additionally, in Prolia-treated men with nonmetastatic prostate cancer receiving ADT, a greater incidence of cataracts was observed. Nonmetastatic means the cancer hasnt spread to other areas of the body. See your dentist regularly. WebMost people can get adequate calcium through their diet if they make an effort. Women Call your doctor at once if you have: new or unusual pain in your thigh, hip, or groin; severe pain in your joints, muscles, or bones; skin problems such as dryness, peeling, redness, itching, blisters, bumps, oozing, or crusting; or. If your doctor says this is safe for you, youll be shown how to inject the medication. But doing so can cause more bone breakdown and increase your risk for bone fractures. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. For more information on this side effect, see Side effect specifics below. Symptoms of a severe allergic reaction can include swelling under your skin, typically in your eyelids, lips, hands, or feet. Continue reading, Prolia (denosumab) does increase bone density. Store in the original container away from heat and light. This includes proper brushing, flossing, mouthwash use, and regular professional dental cleanings. generic drugs) are not considered. It is given by a health care professional in a hospital or clinic setting. Talk with your doctor or health care professional about your birth control options while taking this medicine. (2022). Your FRAX score is your risk of having an osteoporosis-related fracture in the next 10 years. Common side effects of this osteoporosis treatment injection include muscle, joint, and back pain. Tell your doctor if you become pregnant. Symptoms may include jaw pain or numbness, red or swollen gums, loose teeth, gum infection, or slow healing after dental work. Doing so will help to prevent dental problems. But if they become bothersome, talk with your doctor or pharmacist. Symptoms may include jaw pain, swelling, numbness, loose teeth, gum infection, or slow healing after injury or surgery involving the gums. Doing so will help you avoid the risk for a low calcium level during treatment. (such as prednisone) for at least six months and are at high risk for fracture. (2021). RA is an autoimmune condition in which your immune system attacks your joints. It is important for you to practice good mouth care during treatment with Prolia. You should always consult your doctor or another healthcare professional before taking any medication. (Biologic medications are made from living organisms.). Generic name: denosumab (Prolia) [den-OH-sue-mab] Prolia is also available in a biosimilar form. WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health. They can tell you more about benefits and risks of Prolia and Forteo. Prolia can cause many serious side effects. If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date. For more information, you can refer to the drugs prescribing information. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. And be sure to let your doctor know about all the medications youre currently taking. But certain choices and habits accelerate the process. After your treatment with Prolia is stopped, or if you skip or delay taking a dose, your risk for breaking bones, including bones in your spine, is increased. Thyroid or parathyroid surgery. If your pain is more severe, your doctor may suggest prescription pain medication or physical therapy. Will my fracture risk come back if I stop Prolia treatment? They can also tell you about other treatment options available for osteoporosis and bone loss prevention. Take calcium and vitamin D as your doctor tells you to help prevent low blood calcium. Youll receive Prolia doses from a healthcare professional. If youre pregnant or breastfeeding, or considering either, talk with your doctor. In addition, your doctor will most likely recommend that you take calcium and vitamin D supplements while taking bisphosphonates, since vitamin D helps your body to absorb calcium. If youve noticed hair loss since starting Prolia treatment, talk with your doctor. Certain kidney problems, such as chronic kidney failure, can cause a low calcium level in your blood. Keep out of the reach of children and pets. If you notice any tooth or jaw pain, or sensitivity while using Prolia, talk with your doctor or dentist right away. Our website services, content, and products are for informational purposes only. These side effects may be temporary, lasting a few days or weeks. All rights reserved. They may recommend ways to ease your symptoms and determine whether you should keep taking Prolia. 2023 Healthline Media LLC. Studies of Prolia didnt report weight gain as a side effect of the drug. Costs of prescription drugs can vary depending on many factors. Your doctor may also recommend other treatments with Prolia to help increase your bone mass. Serious side effects of Prolia that have been reported include: For most people, Prolias side effects are mild and go away after a few days to a few weeks. Do any of yall know? If you have serious side effects from Prolia, call your doctor right away. In addition, you should use effective birth control while youre taking Prolia. This is called hypocalcemia. Brush and floss your teeth as directed. As with most drugs, Prolia can cause an allergic reaction in some people. But Prolia is given once every 6 months by a healthcare professional. With osteopenia, your bone mineral density (BMD) is lower than usual. Most Medicare plans and other insurance plans cover Prolia. It may not cover all possible information. WebYour doctor may prescribe calcium and vitamin D to help prevent low calcium levels in Your doctor or pharmacist can tell you more about the potential side effects of Prolia and ways to reduce them. All rights reserved. But if you look at D3 supplements online, youll see that most commercial supplements have higher doses usually either 1,000, 2,000, 5,000 or 10,000 IU. Specifically, Prolia works by blocking a protein called RANK. If you need to have any dental work (especially surgery), tell the dentist ahead of time that you are using Prolia. Prolia injection is a brand of denosumab, which treats osteoporosis. You may report side effects to FDA at 1-800-FDA-1088. They can also suggest ways to relieve this side effect. Xgeva is used to treat a high calcium level due to cancer and to prevent bone fractures and other bone problems caused by multiple myeloma or cancer bone metastases. Its recommended that you take 400 international units of vitamin D and 1,000 milligrams (mg) of calcium with Prolia. All subjects in the clinical trials of Prolia received 800mg of calcium and But before taking Prolia, be sure to tell your doctor about all medications you take (including prescription and over-the-counter types). Advertising on our site helps support our mission. Not getting enough calcium in your diet can lead to fragile, brittle bones that are more prone to fractures and disease. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. These articles might help: Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. You should also talk with them if you have any serious side effects during Prolia treatment. If youre able to become pregnant, your doctor will have you take a pregnancy test before you start Prolia treatment. Call your doctor for medical advice about side effects. This makes your bones weak and increases your risk for bone fractures or breaks. Musculoskeletal pain from Prolia is mild or manageable for most people. Its not known if Prolia is safe or effective for use in children. Below are commonly used dosages, but the dosage you receive will be determined by your doctor. Prolia is a prescription medicine used to treat bone loss in men who are at high risk for fracture receiving certain treatments If you are a healthcare professional, click "I Agree" to continue. Before you start Prolia treatment, talk with your doctor about how long Prolias side effects may last. Talk with your doctor about which medication is right for you. Inflammation of the inner lining of the heart (endocarditis) due to an infection may also happen more often in people who take Prolia. Other studies have examined the risk of damage to jaw tissue with the use of bisphosphonates, one type of medication commonly used to treat osteoporosis. Learn how estrogen affects bone health and how you can protect yourself from bone loss, Osteoporosis is more common in women than men, but it affects millions of men every year. You may need to go to the hospital for treatment. Pain, specifically musculoskeletal pain, is one of the most common side effects of Prolia. For example, if you have a serious UTI or other infection, call your doctor right away. This may include acetaminophen (Tylenol), naproxen (Aleve), or ibuprofen (Advil, Motrin). Prolia is a prescription medicine used to treat osteoporosis in women after menopause who are at high risk for fracture Theres no information available to know whether Prolia is passed into breast milk or if its safe to take while breastfeeding. Call your doctor for medical advice about side effects. WebYou should take calcium and vitamin D as your doctor tells you to while you receive Prolia is also used to treat glucocorticoid-induced osteoporosis in men and women at high risk of bone fracture. Yoga is an excellent way to manage symptoms of osteoporosis. Since different people What osteoporosis medications are there, and what side effects do they have? You should not breastfeed while using this medicine. Coming to a Cleveland Clinic location?Hillcrest Cancer Center check-in changesCole Eye entrance closingVisitation and COVID-19 information, Notice of Intelligent Business Solutions data eventLearn more. Instead, it belongs to a different group of medications called biologics. If your dizziness doesnt go away or becomes severe, talk with your doctor. Prolia 60 mg/1 mL in a single-dose prefilled syringe (medicine). NOTE: This medicine is only for you. Do not stop, skip or delay taking Prolia without first talking with your doctor. Adults over age 50 should not exceed 2,000 mg total per day. They have some similar uses and side effects, but they also have some differences. Whats the Connection Between Estrogen and Osteoporosis? It is advisable to take 2 capsules in the morning with food and 1 in the evening also with food. Tingling or numbness in the hands, feet, and face can develop as a symptom of severe hypocalcemia. This may help to protect healthy cells from damage. For this reason, some calcium supplements are combined with vitamin D. This vitamin is available in two forms, vitamin D 2 (ergocalciferol) and vitamin How Viagra became a new 'tool' for young men, Ankylosing Spondylitis Pain: Fact or Fiction, https://www.ada.org/en/member-center/oral-health-topics/osteoporosis-medications, https://www.accessdata.fda.gov/drugsatfda_docs/label/2022/125320s210lbl.pdf, New clues to slow aging? And some of these side effects are more common with certain uses of Prolia. They will also explain how much youll be given and how often. (BMD is a measurement of the amount of minerals such as calcium in your bones.) What do I need to be aware of if I need a tooth extraction while Im using Prolia? Any advice? And if you have osteoporosis, falling could increase your risk of fractures. low calcium level--muscle spasms or contractions, numbness or tingly feeling (around your mouth, or in your fingers and toes). Learn about compression fractures, preventive medications, and, Preventing osteoporosis can help you prevent fractures and maintain strength as you age. You might be interested in seeing how Prolia and the drug Boniva compare. It is not safe to receive Prolia during pregnancy. Your doctor or pharmacist can tell you about any interactions these may cause with Prolia. Your doctor or health care professional may order blood tests and other tests to see how you are doing. Pay special attention to your dental hygiene. A healthcare provider will give you this injection in a hospital or clinic. This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions. And in my mind, that's no different than scheduling a visit to the dentist twice a year. But if you think youre having a medical emergency, call 911 or your local emergency number. Over time, Prolia helps to improve the density and strength of your bones by slowing bone loss. If youre concerned about hair loss with Prolia, talk with your doctor. Do not share this medicine with another person, even if they have the same symptoms you have. What are the possible side effects of Prolia? This drug may decrease your body's ability to fight infection. Use of this site constitutes acceptance of eHealthMe.com's terms of service and privacy policy. Your doctor can also advise you on symptoms of low calcium to look for. These problems may include: Your risk for mouth-related side effects may be higher if you have problems with your teeth. If youre using Prolia and feel fatigued despite getting enough sleep, talk with your doctor. And ask your doctor about which drug is right for your condition. But if your symptoms are serious and you think youre having a medical emergency, immediately call 911 or your local emergency number. How long will I need to keep taking Prolia? Find out why people need calcium, which foods provide it, and what happens if they consume. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Also, hair loss may be related to other medications you take or health conditions you have. Here are a few tips that might help guide your discussion: Remember, your doctor and other healthcare professionals are available to help you. So your healthcare provider will likely ask you to take calcium and vitamin D supplements if youre not taking them already. To prevent osteoporotic fractures, combined calcium and vitamin D supplementation is recommended at the correct dosage (1,0001,200 mg calcium and 800 IU of vitamin D per day). Supplementation should be targeted on vulnerable groups such as elderly and institutionalised people, patients with osteoporosis and individuals on glucocorticoids. Numerous trials have shown that calcium and vitamin D supplementation is effective and safe. In particular, no increased cardiovascular risk was observed. Calcium supplements may help support bone and teeth health. In addition, Prolia may also be used off-label for other conditions that cause bone loss or loss of bone mineral density. Sciatica is described as a shooting pain that travels from the lower back down a leg. You may take the carton out of the refrigerator and allow it to reach room temperature before the injection is given. Use of the term male in this article refers to sex assigned at birth. A healthcare provider will give you this injection. Having a tooth extraction while youre using Prolia may increase your risk for these side effects. Serious side effects from Prolia can occur, but they arent common. The most common medications prescribed to lower cholesterol are statins. For more information about how Prolia and Zometa compare with each other, see this article. With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. Dizziness from Prolia is usually mild and may go away on its own within a few days or weeks. If you have bothersome or severe side effects or other problems while taking Prolia and need to stop the medication, your doctor will monitor your bone mineral density. Xgeva is another brand of denosumab that treats high calcium levels caused by cancer and prevents bone breaks. But if the side effects last longer than that, bother you, or become severe, be sure to talk with your doctor or pharmacist. Learn more details about some of the side effects that Prolia may cause. Prolia is a RANKL inhibitor. * Sex and gender exist on spectrums. So, dont be afraid to ask questions or offer feedback on your treatment. Some people may have an allergic reaction to Prolia. They can help answer any questions you have about side effects from taking the drug. * Sex and gender exist on spectrums. Denosumab is contraindicated in women with hypocalcaemia. This is because the drug may be harmful to a growing fetus. Some people using Prolia have developed bone loss in the jaw, also called osteonecrosis of the jaw. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. You should take calcium and vitamin D as your doctor tells you to while you receive Prolia. Results may vary. Copyright 1996-2023 Cerner Multum, Inc. If you have a low calcium level, you should not take Prolia. Specifically, Prolia is a monoclonal antibody (a lab-made protein). Monoclonal antibodies are made to target and destroy only certain cells in the body. If you have a male* sexual partner, they should use birth control during this time as well. Increased risk of broken bones, including broken bones in the spine, after stopping, skipping or delaying Prolia. Xgeva is also used to treat giant cell tumor of the bone. Cleveland Clinic is a non-profit academic medical center. A few examples of bisphosphonates include: If youd like to know more about using a bisphosphonate for your condition, talk with your doctor. If you are pregnant, you should not take Prolia. Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a healthcare professional. Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. Do not shake the prefilled syringe. They need to know if you have any of these conditions: This medicine is for injection under the skin. Prolia improves bone mass and increases bone mineral density. Policy. If youve already gone through menopause, your risk for bone loss is increased. However, drinking too much alcohol may raise your risk of falling. Tell your doctor right away if you become pregnant while taking Prolia. Call your doctor or health care professional for advice if you get a fever, chills or sore throat, or other symptoms of a cold or flu. Some examples are atorvastatin (Lipitor) and rosuvastatin (Crestor). Do not take this medicine with any of the following medications: This medicine may also interact with the following medications: This list may not describe all possible interactions. If you have jaw pain or other mouth problems while youre using Prolia, tell your doctor or dentist. They include bone pain, back pain, and a higher risk of certain infections. You will receive your Prolia injection from your healthcare provider at a their office or clinic. Version: 13.01. hydrochlorothiazide, alendronate, Fosamax, calcium carbonate, Premarin, Tymlos. No one in clinical trials of Prolia had to stop taking the drug due to dizziness. But theyre each effective in treating osteoporosis and preventing bone loss. The most common side effects of Prolia in patients with corticosteroid-induced osteoporosis are back pain, high blood pressure, lung infection (bronchitis), and headache. Keep in mind that side effects of a drug can depend on: Additionally, you may experience different side effects from those listed below based on the condition youre treating with Prolia. If youre able to become pregnant, your doctor will order a pregnancy test for you before you take Prolia. Call your doctor or go to your nearest emergency room right away if you have any symptoms of a serious allergic reaction, including low blood pressure (hypotension); trouble breathing; throat tightness; swelling of your face, lips, or tongue; rash; itching; or hives. Theyll discuss with you other treatments to help protect you from fractures and bone loss. Different individuals may respond to medication in different ways. For instance: Both Prolia and Forteo are given as injections under your skin. 2,4. Prolia should not be used during pregnancy. Your doctor will order blood tests to check your level before you start using Prolia and regularly during your treatment. Serious side effects that have been reported and their symptoms include: * To learn more, see Does Prolia cause long-term side effects? in the FAQs about the side effects of Prolia section below. With these reports, it wasnt known whether Prolia or something else (such as a different medication) caused the hair loss. Do not use denosumab if you are pregnant. Before beginning treatment with Prolia, ask your doctor about the benefits and risks of the drug. to treat osteoporosis in males* and in females* whove gone through, to treat osteoporosis caused by long-term use of, metabolic bone disease, such as Hajdu-Cheney syndrome and juvenile.

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